Description

Methyl 2-(2,5-Dioxopyrrolidin-1-yl)benzoate is a high-purity chemical intermediate featuring a reactive N-hydroxysuccinimide (NHS) ester moiety. This compound is critical for facilitating efficient amide bond formation under mild conditions, enabling the synthesis and modification of complex molecules. It is primarily sought by research institutions and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing active pharmaceutical ingredients (APIs), peptide conjugates, and functionalized polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation Reagent: Used for labeling proteins, antibodies, and peptides with fluorescent dyes, drugs, or other functional molecules.
• Polymer Chemistry: Serves as a functional monomer or cross-linking agent for creating specialty polymers with tailored properties.
• Proteomics Research: Employed in chemical proteomics for activity-based protein profiling and identifying enzyme substrates.
• Diagnostic Reagent Synthesis: Utilized in the manufacture of components for immunoassays and diagnostic kits.
• Material Science: Facilitates surface functionalization of nanoparticles and other nanomaterials for biomedical applications.

Basic Information

Product Name	Methyl 2-(2,5-Dioxopyrrolidin-1-yl)benzoate
CAS No.	77741-53-8
Molecular Formula	C13H11NO5
Molecular Weight	261.23 g/mol
Synonyms	1-(2-(Methoxycarbonyl)phenyl)-2,5-pyrrolidinedione; Methyl 2-(2,5-dioxo-1-pyrrolidinyl)benzoate; 2-(N-Succinimidyl)benzoic acid methyl ester; Methyl o-(N-succinimidyl)benzoate; NHS-Activated Benzoate Ester; 77741-53-8; Benzoic acid, 2-(2,5-dioxo-1-pyrrolidinyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-(2,5-Dioxopyrrolidin-1-yl)benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.