Description

4-tert-Butoxycarbonylamino-1-Methyl-1H-Pyrrole-2-Carboxylic Acid Benzotriazol-1Yl Ester is a specialized, high-purity chemical building block primarily used in advanced organic synthesis. This compound is valued for its role as an activated ester, facilitating efficient peptide coupling and amide bond formation under mild conditions. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of novel active pharmaceutical ingredients (APIs) and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those containing pyrrole or peptide motifs.
• Peptide Synthesis: Serves as an activated ester reagent for coupling amino acids and constructing peptide chains in solid-phase and solution-phase synthesis.
• Protecting Group Chemistry: Utilized in multi-step organic synthesis where the tert-butoxycarbonyl (Boc) group protects amines.
• Heterocyclic Compound Research: Fundamental for constructing and functionalizing pyrrole-based scaffolds in medicinal chemistry and material science.
• Bioconjugation: Used in the modification of biomolecules for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	4-tert-Butoxycarbonylamino-1-Methyl-1H-Pyrrole-2-Carboxylic Acid Benzotriazol-1Yl Ester
CAS No.	77716-16-6
Molecular Formula	C19H23N5O4
Molecular Weight	385.42 g/mol
Synonyms	1H-Pyrrole-2-carboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-methyl-, 1-(1H-benzotriazol-1-yl) ester; 4-(Boc-amino)-1-methyl-1H-pyrrole-2-carboxylic acid benzotriazol-1-yl ester; Boc-Pyrrole(Me)-OBt; 4-(tert-Butoxycarbonylamino)-1-methyl-1H-pyrrole-2-carboxylic acid 1-benzotriazolyl ester; 1-(Benzotriazol-1-yl) 4-[(tert-butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylate; Bt ester of Boc-protected methylpyrrole carboxylic acid; CAS 77716-16-6
EINECS	Contact for details

Quality Control

Our production of 4-tert-Butoxycarbonylamino-1-Methyl-1H-Pyrrole-2-Carboxylic Acid Benzotriazol-1Yl Ester adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.