Description

α-Methoxy-α-(Trifluoromethyl)Benzeneacetic Acid Methyl Ester is a high-value fluorinated synthetic intermediate characterized by its α-methoxy-α-trifluoromethylphenylacetate (MTPA ester) structure. This compound is critically important as a versatile chiral derivatizing agent and building block for the preparation of enantiomerically pure pharmaceuticals and agrochemicals. It is essential for research and production laboratories specializing in asymmetric synthesis, process chemistry, and the development of active pharmaceutical ingredients (APIs).

Application

• Chiral Derivatizing Agent: Widely used in nuclear magnetic resonance (NMR) spectroscopy for determining the enantiomeric purity and absolute configuration of chiral alcohols, amines, and carboxylic acids.
• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of enantiomerically enriched drug candidates, particularly those containing a trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Employed in the production of advanced, optically active pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Preparation: Used in the development of chiral ligands and organocatalysts for asymmetric catalytic reactions.
• Analytical Chemistry Standard: Acts as a reference standard in chromatographic methods (HPLC, GC) for the analysis of chiral compounds.
• Fine Chemical Research: A fundamental reagent in academic and industrial R&D for exploring new methodologies in fluoroorganic and stereoselective chemistry.

Basic Information

Product Name	α-Methoxy-α-(Trifluoromethyl)Benzeneacetic Acid Methyl Ester
CAS No.	77611-72-4
Molecular Formula	C12H11F3O3
Molecular Weight	260.21 g/mol
Synonyms	Methyl (R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetate; (R)-MTPA Methyl Ester; (R)-(+)-Methoxy(trifluoromethyl)phenylacetic Acid Methyl Ester; (R)-Mosher's Acid Methyl Ester; α-Methoxy-α-trifluoromethylphenylacetic Acid Methyl Ester; Methyl 2-Methoxy-2-(trifluoromethyl)phenylacetate; (R)-α-Methoxy-α-(trifluoromethyl)benzeneacetic Acid Methyl Ester; (R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our α-Methoxy-α-(Trifluoromethyl)Benzeneacetic Acid Methyl Ester is manufactured under strict quality control protocols to ensure high chemical and enantiomeric purity, meeting the exacting standards of advanced synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, enantiomeric excess (e.e.), and impurity profile. Our quality systems support compliance with cGMP and ISO standards for reliable, batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% e.e. (R-isomer)
Specific Rotation [α]D20	+65° to +75° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.