Description

Lovastatin Acid Ammonium Salt is a key pharmaceutical intermediate derived from the natural statin, lovastatin. This compound is valued for its role in the synthesis of more potent cholesterol-lowering agents and for use in advanced pharmaceutical research. It is primarily utilized by manufacturers and R&D laboratories in the pharmaceutical and biotechnology sectors for developing new therapeutic formulations and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of semi-synthetic statins and other advanced cholesterol management drugs.
• Active Pharmaceutical Ingredient (API) Development: Used in research and production for developing new statin-based APIs with improved efficacy and safety profiles.
• Biochemical Research: Serves as a reference standard and tool compound in studies investigating HMG-CoA reductase inhibition and lipid metabolism pathways.
• Preclinical & Clinical Studies: Employed in the formulation of drug candidates for pharmacokinetic, pharmacodynamic, and toxicology testing.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for statin production under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	Lovastatin Acid Ammonium Salt
CAS No.	77550-67-5
Molecular Formula	C24H38O5 • H3N
Molecular Weight	423.56 g/mol
Synonyms	Ammonium Lovastatin Hydroxy Acid; Monacolin J Ammonium Salt; (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl (2S)-2-methylbutanoate Ammonium Salt; 6α-Methylcompactin Ammonium Salt; Mevinolinic Acid Ammonium Salt; LOVASTATIN Related Compound A (Ammonium Salt); NSC 339428 Ammonium Salt
EINECS	Contact for details

Quality Control

Our Lovastatin Acid Ammonium Salt is produced and tested to meet stringent quality standards suitable for pharmaceutical applications. Each batch undergoes comprehensive analysis, including identity confirmation, purity assay, and impurity profiling via advanced chromatographic techniques. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.