Description

Dihydromevinolin is a potent, reduced form of mevinolin, a key intermediate in the biosynthesis of cholesterol-lowering statin drugs. This compound is of significant value in pharmaceutical research and development, particularly for studying enzyme inhibition mechanisms and metabolic pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors for developing novel therapeutic agents and reference standards.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of statin-class drugs and other bioactive molecules targeting HMG-CoA reductase.
• Biochemical Research: Used as a reference standard and inhibitor in enzymatic studies related to cholesterol biosynthesis and metabolic disorders.
• Fine Chemical Synthesis: Serves as a building block for the preparation of complex, high-value chemical entities in medicinal chemistry.
• Analytical Standard: Employed in quality control laboratories for method development, validation, and calibration in HPLC and LC-MS analyses.
• Metabolite Studies: Utilized in pharmacokinetic and metabolic pathway research to understand drug action and biotransformation.

Basic Information

Product Name	Dihydromevinolin
CAS No.	77517-29-4
Molecular Formula	C24H38O5
Molecular Weight	406.56 g/mol
Synonyms	Dihydromevinolin; Dihydromevinolin K; (3R,5R)-7-[(1S,2S,6S,8S,8aR)-8-Hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid δ-lactone; Dihydrocompactin; ML-236B; Monacolin J; L-154,803; Antibiotic L 154,803
EINECS	Contact for details

Quality Control

Our Dihydromevinolin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.