Description

(-)-1,1'-Dithiodiethylenebis[3-(2-Chloroethyl)-3-Nitrosourea] is a specialized, high-potency nitrosourea derivative distinguished by its unique dithiodiethylene linker. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential as a bifunctional alkylating agent. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, especially in the fields of oncology and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Used as a tool compound in studies investigating DNA alkylation, cross-linking mechanisms, and the development of prodrug systems.
• Antitumor Agent Development: A key precursor for research into nitrosourea-based compounds with potential antitumor and antineoplastic activity.
• Prodrug Synthesis: Employed in the design and synthesis of prodrugs that utilize disulfide bond cleavage for targeted drug release.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and reduce toxicity.
• Academic & Institutional Research: Supplied to universities and R&D labs for fundamental studies in organic synthesis and bio-conjugation chemistry.

Basic Information

Product Name	(-)-1,1'-Dithiodiethylenebis[3-(2-Chloroethyl)-3-Nitrosourea]
CAS No.	77456-14-5
Molecular Formula	C10H16Cl2N6O4S2
Molecular Weight	419.31 g/mol
Synonyms	1,1'-Dithiodi-2,2'-ethanediylbis[1-(2-chloroethyl)-1-nitrosourea]; Bifunctional Chloroethylnitrosourea; 1,1'-[Dithiobis(ethylene)]bis[1-(2-chloroethyl)-1-nitrosourea]; Nitrosourea dimer; Disulfide-linked nitrosourea; DTNU; Research Compound 77456-14-5
EINECS	Contact for details

Quality Control

Our (-)-1,1'-Dithiodiethylenebis[3-(2-Chloroethyl)-3-Nitrosourea] is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable for pharmaceutical intermediates, and specifications can be aligned with client-specific research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.