Description

4-Nitrobenzyl Hydrogen Malonate is a versatile and high-purity organic intermediate of significant importance in advanced chemical synthesis. This compound is valued for its reactive malonate ester functionality and the nitrobenzyl protecting group, making it a critical building block for the production of complex molecules. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring malonate ester chemistry.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where specific ester linkages are required.
• Peptide Mimetics & Prodrug Development: Serves as a precursor for creating peptide analogs and prodrug systems that utilize the nitrobenzyl group as a photolabile protecting group.
• Organic Synthesis Reagent: Employed in various organic transformations, including alkylation and condensation reactions, to construct complex carbon skeletons.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of novel polymers and functional materials.
• Chemical Biology Probes: Utilized in the design and synthesis of probes and tags for studying biological processes.

Basic Information

Product Name	4-Nitrobenzyl Hydrogen Malonate
CAS No.	77359-11-6
Molecular Formula	C10H9NO6
Molecular Weight	239.18 g/mol
Synonyms	4-Nitrobenzyl Hydrogen Malonate; 4-Nitrobenzyl Malonate Half Ester; 4-Nitrobenzyl Malonic Acid Monoester; Malonic Acid Mono(4-nitrobenzyl) Ester; 2-(4-Nitrobenzyloxy)-2-oxoacetic Acid; (4-Nitrobenzyl) Hydrogen Propanedioate; Propanedioic Acid, Mono(4-nitrobenzyl) Ester; 4-Nitrobenzyl Malonate
EINECS	Contact for details

Quality Control

Our 4-Nitrobenzyl Hydrogen Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency meet the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.