Description

3-Trimethylsilyloxy-7-Ketolithocholic Methyl Ester is a key synthetic intermediate in the production of advanced pharmaceutical compounds. Its value lies in its role as a protected derivative of lithocholic acid, enabling precise chemical modifications for drug discovery and development. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on developing novel therapeutic agents and conducting metabolic studies.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel bile acid analogs and steroidal drugs.
• Drug Discovery Research: Used in medicinal chemistry for the development of new therapeutic agents targeting metabolic pathways, nuclear receptors (e.g., FXR, TGR5), and liver diseases.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Metabolic Pathway Studies: Employed in biochemical research to investigate bile acid metabolism, synthesis, and related enzymatic processes.
• Process Chemistry Development: Utilized for scaling up synthetic routes and optimizing production processes for advanced pharmaceutical ingredients (APIs).
• Academic & Institutional Research: A valuable reagent for universities and research institutes conducting studies in organic synthesis, steroid chemistry, and pharmacology.

Basic Information

Product Name	3-Trimethylsilyloxy-7-Ketolithocholic Methyl Ester
CAS No.	77341-09-4
Molecular Formula	C₂₈H₄₈O₅Si
Molecular Weight	492.77 g/mol
Synonyms	Methyl 3-[(trimethylsilyl)oxy]-7-oxo-5β-cholan-24-oate; 7-Ketolithocholic Acid Methyl Ester 3-Trimethylsilyl Ether; Methyl 3-trimethylsilyloxy-7-oxo-5β-cholan-24-oate; 3-TMS-7-KLCA Methyl Ester; 3-(Trimethylsiloxy)-7-oxolithocholic Acid Methyl Ester; 5β-Cholan-24-oic Acid, 3-[(Trimethylsilyl)oxy]-7-oxo-, Methyl Ester; 3-Trimethylsilyloxy-7-oxolithocholic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 3-Trimethylsilyloxy-7-Ketolithocholic Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.