Description

4-(2-Cyano-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Peptidomimetic Chemistry: Used to introduce the piperazine scaffold with a protected carboxylic acid and a cyanoethyl side chain, which can be further functionalized.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal complexation.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides that incorporate heterocyclic amine structures.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.
• Academic and Institutional Research: Used in university and institutional labs for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	4-(2-Cyano-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	77278-86-5
Molecular Formula	C12H21N3O2
Molecular Weight	239.32 g/mol
Synonyms	1-Boc-4-(2-cyanoethyl)piperazine; tert-Butyl 4-(2-cyanoethyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(2-cyanoethyl)piperazine; 4-(2-Cyanoethyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(2-cyanoethyl)piperazine; Piperazine-1-carboxylic acid, 4-(2-cyanoethyl)-, 1,1-dimethylethyl ester; BOC-Piperazine-C2-CN
EINECS	Contact for details

Quality Control

Every batch of 4-(2-Cyano-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with exacting industry standards for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.