Description

n-[S-[2-[Bis(2-Chloroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorin-4-Yl]-n-L-γ-Glutamyl-L-Cysteinyl]Glycine CAS NO 77273-67-7 is a complex, biologically active chemical compound that serves as a key intermediate in advanced pharmaceutical synthesis. This molecule is of significant interest for its potential role in the development of targeted therapeutic agents, particularly in oncology research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of novel drug candidates and biochemical probes.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of specialized chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Used as a precursor or reference standard in studies involving DNA alkylation mechanisms and cell signaling pathways.
• Anticancer Drug Development: Serves as a core structural component for developing prodrugs and conjugates designed for selective tumor cell targeting.
• Peptide-Based Conjugate Synthesis: Employed in the creation of peptide-drug conjugates (PDCs) due to its integrated glutamyl-cysteinyl-glycine (glutathione analog) moiety.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of related active pharmaceutical ingredients (APIs).
• Mechanistic Studies: Applied in preclinical research to investigate the metabolism and mode of action of nitrogen mustard-derived pharmaceuticals.

Basic Information

Product Name	n-[S-[2-[Bis(2-Chloroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorin-4-Yl]-n-L-γ-Glutamyl-L-Cysteinyl]Glycine
CAS No.	77273-67-7
Molecular Formula	C₁₆H₂₈Cl₂N₅O₇P
Molecular Weight	512.30 g/mol
Synonyms	L-Glutathione, S-[2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl]-; Cyclophosphamide-Glutathione Conjugate; 4-Hydroxycyclophosphamide Glutathione Conjugate; Aldophosphamide Glutathione Adduct; GST Conjugate of 4-Hydroxycyclophosphamide; NSC 758439; Glutathionyl-4-hydroxycyclophosphamide; Detoxification Metabolite of Cyclophosphamide
EINECS	Contact for details

Quality Control

Our n-[S-[2-[Bis(2-Chloroethyl)Amino]Tetrahydro-2H-1,3,2-Oxazaphosphorin-4-Yl]-n-L-γ-Glutamyl-L-Cysteinyl]Glycine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) detailing specific batch results are available upon request, providing full traceability and compliance data.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the product should be stored in a cool, dry place, ideally under controlled room temperature (15-25°C). For long-term stability, consider storage under an inert atmosphere. Keep the container tightly sealed when not in use to prevent degradation from moisture and air.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.