Description

Dimethyl 1,1'-Methylenebis[5-Oxo-L-Prolinate] is a high-purity, specialized chemical intermediate derived from L-proline. This compound matters for its role as a key building block in the synthesis of complex molecules, offering precise stereochemistry and functional group compatibility. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing advanced active pharmaceutical ingredients (APIs) and novel organic compounds.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of complex drug candidates, particularly those requiring proline-derived scaffolds.
• Peptidomimetics Research: Used in academic and industrial R&D to create novel peptide analogs and conformationally constrained molecules.
• Catalyst Ligand Synthesis: Serves as a precursor for developing specialized ligands used in asymmetric catalysis.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value specialty chemicals and advanced materials.
• Bioconjugation Chemistry: Potential use in creating linkers or functional handles for bioconjugation applications in drug delivery systems.

Basic Information

Product Name	Dimethyl 1,1'-Methylenebis[5-Oxo-L-Prolinate]
CAS No.	77269-11-5
Molecular Formula	C₁₄H₂₀N₂O₆
Molecular Weight	312.32 g/mol
Synonyms	Dimethyl (2S,2'S)-1,1'-Methylenebis(5-oxopyrrolidine-2-carboxylate); L-Proline, 5-oxo-, 1,1'-methylenedi-, dimethyl ester; Dimethyl Ester of 1,1'-Methylenebis(5-oxo-L-proline); Bis(methyl 5-oxo-L-prolinate) methane; Proline-derived dimethylene diester
EINECS	Contact for details

Quality Control

Our Dimethyl 1,1'-Methylenebis[5-Oxo-L-Prolinate] is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting identity, purity, and specific tests are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.