Description

4-(Trifluoroacetamido)Pyridine is a specialized fluorinated pyridine derivative that serves as a high-value synthetic intermediate. This compound is particularly significant for introducing the trifluoroacetamido functional group, which can impart desirable properties such as metabolic stability and enhanced lipophilicity to target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for improved bioavailability and metabolic resistance.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides where the trifluoroacetamido group can enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis.
• Material Science: Employed in the synthesis of advanced polymers and organic electronic materials where fluorine incorporation can modify electronic properties and stability.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in proteomics and diagnostic assay development due to its reactive amide linkage.
• Custom Synthesis and Scale-up: A critical starting material for contract research and manufacturing organizations (CROs/CMOs) serving the life sciences sector.

Basic Information

Product Name	4-(Trifluoroacetamido)Pyridine
CAS No.	77262-39-6
Molecular Formula	C7H5F3N2O
Molecular Weight	190.12 g/mol
Synonyms	4-(Trifluoroacetamido)pyridine; N-(Pyridin-4-yl)-2,2,2-trifluoroacetamide; 4-(2,2,2-Trifluoroacetamido)pyridine; 4-Pyridinyltrifluoroacetamide; 4-Trifluoroacetamidopyridine; 4-Aminopyridine trifluoroacetamide derivative; p-(Trifluoroacetamido)pyridine; TFAP
EINECS	Contact for details

Quality Control

Our 4-(Trifluoroacetamido)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with each shipment and are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.