Description

Carboxyprimaquine is a key chemical intermediate and metabolite of the antimalarial drug primaquine. This compound is of significant interest in pharmaceutical research and development, particularly for the synthesis and metabolic study of antiparasitic agents. It serves as a critical building block for medicinal chemists and researchers in the pharmaceutical and life sciences industries who are developing or analyzing therapeutic compounds for malaria and related diseases.

Application

• Pharmaceutical Intermediate: Primary use as a synthetic precursor in the manufacture of primaquine and related antimalarial APIs.
• Metabolite Reference Standard: Essential for pharmacokinetic and pharmacodynamic studies, used as a standard in bioanalytical methods (HPLC, LC-MS) to quantify drug metabolism.
• Medicinal Chemistry Research: A valuable scaffold for the design, synthesis, and structure-activity relationship (SAR) studies of new quinoline-based therapeutic agents.
• Biochemical Research: Used in enzymatic and cellular assays to investigate the mechanism of action and metabolic pathways of 8-aminoquinoline drugs.
• Impurity Standard: Serves as a certified reference material for quality control, ensuring the purity and safety of pharmaceutical products by identifying and quantifying related substances.

Basic Information

Product Name	Carboxyprimaquine
CAS No.	77229-68-6
Molecular Formula	C₁₅H₂₁N₃O₃
Molecular Weight	291.35 g/mol
Synonyms	5-[(4-Amino-1-methylbutyl)amino]-2-carboxyquinoline; 5-(4-Amino-1-methylbutylamino)quinoline-2-carboxylic Acid; Carboxy Primaquine; Primaquine Carboxylic Acid; NSC 351939; 2-Quinolinecarboxylic acid, 5-[(4-amino-1-methylbutyl)amino]-
EINECS	Contact for details

Quality Control

Our Carboxyprimaquine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specific impurities. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all test results against our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.