Description

Methyl 3-((Trimethylsilyl)ethynyl)benzoate is a versatile organosilicon building block featuring both a silyl-protected alkyne and a benzoate ester functional group. This compound is valued for its role in advanced organic synthesis, particularly in cross-coupling reactions and as a precursor to complex molecular architectures. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and materials science industries for constructing novel compounds and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring alkyne or aromatic ester motifs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that incorporate silicon and alkyne functionalities.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the production of specialty polymers, resins, and advanced organic electronic materials.
• Cross-Coupling Reactions: An essential reagent in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Chemical Synthesis Building Block: Provides a protected alkyne group for sequential deprotection and functionalization in multi-step synthetic routes.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Methyl 3-((Trimethylsilyl)ethynyl)benzoate
CAS No.	77123-59-2
Molecular Formula	C13H16O2Si
Molecular Weight	232.35 g/mol
Synonyms	3-[(Trimethylsilyl)ethynyl]benzoic acid methyl ester; Methyl m-((trimethylsilyl)ethynyl)benzoate; Benzoic acid, 3-[(trimethylsilyl)ethynyl]-, methyl ester; Methyl 3-(2-trimethylsilylethynyl)benzoate; TMS-protected methyl 3-ethynylbenzoate; m-(Methoxycarbonyl)phenyl(trimethylsilyl)acetylene
EINECS	Contact for details

Quality Control

Our production of Methyl 3-((Trimethylsilyl)ethynyl)benzoate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.