Description

1-Chloro-5-(Trimethylsilyl)-4-Pentyne is a specialized organosilicon building block featuring both a terminal alkyne and a reactive chloroalkyl group. This bifunctional structure makes it a valuable intermediate for advanced organic synthesis, particularly in the construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as cross-coupling reactions and the synthesis of novel silicon-containing compounds.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for introducing silicon or alkyne functionalities.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where its unique structure can contribute to biological activity.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers, resins, and silicon-based hybrid materials.
• Organic Synthesis Building Block: Employed in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to create complex organic molecules.
• Ligand and Catalyst Development: Useful for synthesizing novel ligands for catalysis or as a precursor for metal-organic frameworks (MOFs).
• Research & Development: A critical tool in academic and industrial R&D labs for exploring new chemical spaces and reaction methodologies.

Basic Information

Product Name	1-Chloro-5-(Trimethylsilyl)-4-Pentyne
CAS No.	77113-48-5
Molecular Formula	C8H15ClSi
Molecular Weight	174.74 g/mol
Synonyms	5-Chloro-1-(trimethylsilyl)-1-pentyne; 1-Pentyne, 5-chloro-1-(trimethylsilyl)-; (5-Chloro-1-pentyn-1-yl)trimethylsilane; Trimethyl((5-chloropent-1-yn-1-yl))silane; 5-Chloro-1-trimethylsilyl-1-pentyne; Chloro(trimethylsilyl)pentyne
EINECS	Contact for details

Quality Control

Our 1-Chloro-5-(Trimethylsilyl)-4-Pentyne is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, NMR, and HPLC analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to the reactive chloro and alkyne groups, it is recommended to store under an inert atmosphere for long-term stability and to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.