Description

Chlorambucil Isopropyl Ester is a chemically modified derivative of the alkylating agent chlorambucil, designed to alter its pharmacokinetic profile. This esterification is crucial for enhancing lipophilicity, which can influence absorption, distribution, and targeted delivery in research applications. It serves as a key synthetic intermediate and reference standard for pharmaceutical R&D, particularly in oncology and medicinal chemistry. The compound is essential for researchers and manufacturers developing novel chemotherapeutic agents and studying structure-activity relationships.

Application

• Pharmaceutical Intermediate: Critical building block in the synthetic pathway for novel alkylating antineoplastic agents and prodrug development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of ester modifications on potency, selectivity, and metabolic stability.
• Reference Standard: Serves as an analytical standard for quality control and method development in API (Active Pharmaceutical Ingredient) manufacturing.
• Biochemical Research: Employed in vitro studies to explore mechanisms of DNA alkylation and cellular apoptosis pathways.
• Prodrug Synthesis: A precursor molecule for designing prodrugs aimed at improving therapeutic index and reducing systemic toxicity.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental cancer research and drug discovery projects.

Basic Information

Product Name	Chlorambucil Isopropyl Ester
CAS No.	77063-20-8
Molecular Formula	C16H23Cl2NO2
Molecular Weight	332.27 g/mol
Synonyms	4-[Bis(2-chloroethyl)amino]benzenebutanoic Acid Isopropyl Ester; Isopropyl 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrate; Chlorambucil Isopropylester; Chlorambucil Isopropyl Ester; Leukeran Isopropyl Ester (analog); CB-Isopropyl Ester; p-[N,N-Bis(2-chloroethyl)amino]phenylbutyric Acid Isopropyl Ester
EINECS	Contact for details

Quality Control

Our Chlorambucil Isopropyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and identification (IR, NMR). Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.