Description

n-(Methylsulfonyl)-N,o-Bis(Trimethylsilyl)Hydroxylamine is a specialized organosilicon reagent featuring a protected hydroxylamine functionality. This compound is a critical building block in advanced organic synthesis, particularly for the controlled introduction of nitrogen and oxygen functionalities. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Serves as a key reagent for the preparation of novel amine derivatives, sulfonamides, and heterocyclic compounds in drug discovery and development.
• Agrochemical Research: Employed in the synthesis of experimental herbicides, fungicides, and plant growth regulators requiring specific nitrogen-oxygen motifs.
• Advanced Material Precursor: Used in the development of silicon-containing polymers and surface-modifying agents where silyl-protected functional groups are advantageous.
• Cross-Coupling & Functionalization Reactions: Acts as a unique nitrogen source in palladium-catalyzed cross-coupling reactions and other metal-mediated transformations.
• Protecting Group Strategy: The trimethylsilyl (TMS) groups provide a protective strategy for the hydroxylamine moiety, allowing for selective deprotection in multi-step syntheses.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry laboratories focused on new synthetic methodologies.

Basic Information

Item	Detail
Product Name	n-(Methylsulfonyl)-N,o-Bis(Trimethylsilyl)Hydroxylamine
CAS No.	76802-31-8
Molecular Formula	C9H25NO3SSi2
Molecular Weight	283.55 g/mol
Synonyms	N-(Methylsulfonyl)-N,O-bis(trimethylsilyl)hydroxylamine; O,N-Bis(trimethylsilyl)-N-(methylsulfonyl)hydroxylamine; Bis(trimethylsilyl) (methylsulfonyl)hydroxylamine; TMS-protected methanesulfonyl hydroxylamine; Hydroxylamine, N-(methylsulfonyl)-N,O-bis(trimethylsilyl)-
EINECS	Contact for details

Quality Control

Every batch of n-(Methylsulfonyl)-N,o-Bis(Trimethylsilyl)Hydroxylamine is manufactured and tested under strict quality management protocols. We ensure high purity and consistency suitable for demanding research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.