Description

Bis(Trimethylsilyl)Acetylenedicarboxylate is a specialized silyl-protected acetylene derivative, a high-value building block in advanced organic synthesis. Its core value lies in enabling the controlled introduction of acetylene dicarboxylate moieties under mild conditions, which is critical for constructing complex molecular architectures. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries, where it serves as a key precursor for heterocyclic compounds, polymers, and functional materials.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing heterocyclic or acetylene-based scaffolds.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators requiring specific acetylene functionalities.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent in the development of specialty polymers, dendrimers, and advanced materials with tailored properties.
• Organic Synthesis Reagent: A versatile reagent for Huisgen cycloaddition (click chemistry) and other coupling reactions to create complex organic molecules in academic and industrial research.
• Ligand & Catalyst Development: Employed in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis and catalytic processes.
• Electronic Chemicals: Potential precursor in the synthesis of organic semiconductors and molecular wires for electronic applications.

Basic Information

Item	Details
Product Name	Bis(Trimethylsilyl)Acetylenedicarboxylate
CAS No.	76734-92-4
Molecular Formula	C12H20O4Si2
Molecular Weight	288.45 g/mol
Synonyms	Acetylenedicarboxylic Acid Bis(trimethylsilyl) Ester; Bis(TMS) Acetylenedicarboxylate; TMS Acetylenedicarboxylate; 2-Butynedioic Acid Bis(trimethylsilyl) Ester; (Trimethylsilyl) Propiolate Dimer; Acetylenedicarboxylic Acid Di(trimethylsilyl) Ester; DTAD (in some contexts); Bis(trimethylsilyl) 2-Butynedioate
EINECS	Contact for details

Quality Control

Our Bis(Trimethylsilyl)Acetylenedicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports applications requiring reliable and reproducible performance in sensitive synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.