Description

Diethyl 2-(2,2,2-Trifluoroacetamido)Malonate is a high-value trifluoromethylated malonate derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a versatile scaffold for constructing complex molecules containing the pharmacologically important trifluoromethyl group. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with improved efficacy and environmental profiles.
• Fluorinated Amino Acid Analog Synthesis: Serves as a precursor for introducing the trifluoroacetamido moiety into peptide mimetics and other bioactive molecules.
• Material Science Research: Employed in the development of fluorinated organic materials and specialty polymers.
• Chemical Biology Probes: Utilized to create labeled compounds and probes for studying biological mechanisms.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical and custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	Diethyl 2-(2,2,2-Trifluoroacetamido)Malonate
CAS No.	76699-09-7
Molecular Formula	C9H12F3NO5
Molecular Weight	271.19 g/mol
Synonyms	Diethyl (2,2,2-Trifluoroacetamido)malonate; 2,2,2-Trifluoro-N-(1,3-diethoxy-1,3-dioxopropan-2-yl)acetamide; 2-(Trifluoroacetamido)malonic Acid Diethyl Ester; Ethyl 2-(2,2,2-Trifluoroacetamido)malonate; Diethyl N-(Trifluoroacetyl)aminomalonate; N-(Trifluoroacetyl)aminomalonic Acid Diethyl Ester; TFAM; DTAM
EINECS	Contact for details

Quality Control

Our Diethyl 2-(2,2,2-Trifluoroacetamido)Malonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.