Description

2-Butanone o-(Trimethylsilylmethyl)Oxime is a specialized organosilicon reagent featuring a protected oxime functional group. This compound is valued for its role as a versatile synthetic building block in advanced organic synthesis, particularly for introducing ketone functionalities under controlled conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring ketone or oxime functionalities.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactive silyl group for selective transformations.
• Organic Synthesis Reagent: Acts as a protected oxime equivalent or a trimethylsilylmethyl anion precursor in various carbon-carbon bond-forming reactions.
• Material Science Research: Employed in the development of specialty polymers and silicon-containing hybrid materials.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed and other metal-mediated coupling reactions to create complex organic molecules.
• Process Chemistry: Investigated for scalable manufacturing routes in fine chemical production due to its stability and handling properties.

Basic Information

Item	Details
Product Name	2-Butanone o-(Trimethylsilylmethyl)Oxime
CAS No.	76681-40-8
Molecular Formula	C8H19NOSi
Molecular Weight	173.33 g/mol
Synonyms	Butanone O-[(Trimethylsilyl)methyl]oxime; 2-Butanone, O-[(trimethylsilyl)methyl]oxime; MEKO-TMS; O-(Trimethylsilylmethyl)acetoxime; (Trimethylsilylmethyl)oxime of 2-Butanone; TMS-Methyl Oxime of MEK
EINECS	Contact for details

Quality Control

Our 2-Butanone o-(Trimethylsilylmethyl)Oxime is produced and tested under a rigorous quality management system. Each batch is analyzed to ensure high chemical purity and consistency, with specifications tailored to meet the demands of research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by GC or HPLC), and impurity profiles is provided with every shipment to ensure full traceability and compliance with your internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.