Description

11 β-(1-Aziridinylmethyl)Estradiol is a synthetic, nitrogen-containing derivative of the natural hormone estradiol, designed for advanced research and pharmaceutical development. This compound is valued for its potential as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel therapeutic agents, particularly in oncology and endocrinology. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing targeted hormone-based therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel steroidal drugs and targeted cancer therapies.
• Biochemical Research: Used as a reference standard or probe in studies investigating estrogen receptor binding, modulation, and signaling pathways.
• Medicinal Chemistry: Acts as a core structure for the design and development of new chemical entities with potential hormonal or anti-hormonal activity.
• API Development: Employed in the development and scale-up processes for potential Active Pharmaceutical Ingredients targeting hormone-responsive conditions.
• Academic Studies: Utilized in university and institutional research for exploring structure-activity relationships (SAR) of modified steroidal compounds.

Basic Information

Product Name	11 β-(1-Aziridinylmethyl)Estradiol
CAS No.	76583-06-7
Molecular Formula	C21H29NO2
Molecular Weight	327.46 g/mol
Synonyms	11β-(1-Aziridinylmethyl)estradiol; 11β-(Aziridin-1-ylmethyl)estra-1,3,5(10)-triene-3,17β-diol; Estradiol, 11β-[(aziridinyl)methyl]-; 11β-(Aziridin-1-ylmethyl)estradiol; 11 β-(Aziridinylmethyl)Estradiol; 11β-Aziridinylmethylestradiol; NSC 716051
EINECS	Contact for details

Quality Control

Our 11 β-(1-Aziridinylmethyl)Estradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.