Description

3-(Difluoromethyl)Pyridine is a versatile fluorinated pyridine derivative, a key building block in modern synthetic chemistry. Its unique structure, featuring a difluoromethyl group on the pyridine ring, makes it a valuable intermediate for introducing fluorine atoms into target molecules, thereby modulating their physicochemical and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides, where the difluoromethyl group can improve efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for specialty chemicals, liquid crystals, and functional materials requiring specific fluorine content.
• Organic Synthesis & Research: A valuable reagent for medicinal chemistry and process R&D, enabling structure-activity relationship (SAR) studies and route scouting.
• Fluorine Chemistry: Employed in the synthesis of more complex fluorinated compounds for various high-value industrial applications.

Basic Information

Product Name	3-(Difluoromethyl)Pyridine
CAS No.	76541-44-1
Molecular Formula	C6H5F2N
Molecular Weight	129.11 g/mol
Synonyms	3-(Difluoromethyl)pyridine; Pyridine, 3-(difluoromethyl)-; 3-Pyridinemethanol, difluoro-; 3-Difluoromethylpyridine; 3-Pyridyl(difluoro)methane; 76541-44-1; Difluoromethyl-3-pyridine
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Pyridine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) documenting full specifications are available upon request, providing transparency and assurance for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong alkalis. Recommended storage temperature is between 2°C and 25°C. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.