Description

2-Chloro-Thiophene-5-Isocyanate is a versatile and highly reactive heterocyclic building block used in advanced organic synthesis. This compound is valued for its ability to introduce the isocyanate functional group onto a chlorinated thiophene scaffold, enabling the creation of novel polymers, agrochemicals, and active pharmaceutical ingredients (APIs). It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries seeking to develop new compounds with tailored properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the thiophene moiety contributes to biological activity.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for the development of specialty polymers, polyurethanes, and coatings with unique thermal or chemical resistance.
• Chemical Research & Development: An essential reagent in organic chemistry labs for constructing complex heterocyclic systems and exploring new reaction pathways.
• Liquid Crystal & Electronic Materials: Potential precursor for materials used in organic semiconductors and liquid crystal displays (LCDs).

Basic Information

Product Name	2-Chloro-Thiophene-5-Isocyanate
CAS No.	76537-13-8
Molecular Formula	C5H2ClNOS
Molecular Weight	159.59 g/mol
Synonyms	5-Isocyanato-2-chlorothiophene; 2-Chloro-5-isocyanatothiophene; 2-Chlorothiophene-5-isocyanate; Thiophene, 2-chloro-5-isocyanato-; 2-Chloro-5-thienyl isocyanate
EINECS	Contact for details

Quality Control

Our 2-Chloro-Thiophene-5-Isocyanate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency. We employ advanced analytical techniques including HPLC, GC, and NMR to verify identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.