Description

4H-Pyrimido(6,1-A)Isoquinolin-4-One, 6,7-Dihydro-9,10-Dimethoxy-2-((2, 4,6-Trimethylphenyl)Amino)-, Hydrochloride, Hydrate (1:1:2) is a high-purity, complex heterocyclic compound primarily utilized as a key pharmaceutical intermediate in advanced research and development. Its intricate molecular structure makes it valuable for synthesizing novel active pharmaceutical ingredients (APIs) and for biochemical studies. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Biochemical Research: Used as a reference standard or probe in enzymatic and receptor-binding studies to understand biological pathways.
• Organic Synthesis: Serves as a versatile precursor for constructing complex polycyclic frameworks in medicinal chemistry.
• Process Development & Scale-Up: Employed in optimizing synthetic routes for the commercial production of target molecules.
• Academic Research: Utilized in university and institutional labs for exploratory chemistry and the development of new synthetic methodologies.

Basic Information

Product Name	4H-Pyrimido(6,1-A)Isoquinolin-4-One, 6,7-Dihydro-9,10-Dimethoxy-2-((2, 4,6-Trimethylphenyl)Amino)-, Hydrochloride, Hydrate (1:1:2)
CAS No.	76536-65-7
Molecular Formula	C23H26N4O3 • HCl • 2H2O
Molecular Weight	484.96 g/mol (monohydrate salt)
Synonyms	2-[(2,4,6-Trimethylphenyl)amino]-6,7-dihydro-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride hydrate; 9,10-Dimethoxy-2-((2,4,6-trimethylphenyl)amino)-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride hydrate; CAS 76536-65-7; 4H-Pyrimido[6,1-a]isoquinolin-4-one, 6,7-dihydro-9,10-dimethoxy-2-((2,4,6-trimethylphenyl)amino)-, hydrochloride, hydrate (1:1:2); 2-Mesitylamino-9,10-dimethoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride dihydrate
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and tested under a strict quality management system. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality protocols are designed to meet the stringent requirements of cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	6.0% - 8.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.