Description

4-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)Benzene-1-Sulphonyl Azide is a specialized chemical intermediate featuring a reactive sulfonyl azide group and a maleimide moiety. This compound is valued for its ability to participate in click chemistry reactions, such as the Staudinger-Bertozzi ligation or copper-free strain-promoted azide-alkyne cycloaddition (SPAAC), enabling efficient and selective bioconjugation. It is primarily sought by research and development teams in the pharmaceutical, biotech, and advanced materials sectors for applications in drug discovery, polymer cross-linking, and surface functionalization.

Application

• Bioconjugation Reagent: Used for site-specific labeling of proteins, antibodies, and oligonucleotides in diagnostic assay development and therapeutic agent production.
• Polymer Modification: Serves as a cross-linking agent or functional monomer for synthesizing advanced polymers with tailored thermal or mechanical properties.
• Surface Functionalization: Enables the covalent attachment of biomolecules or other functional groups to material surfaces (e.g., nanoparticles, chips, beads) for biosensors and medical devices.
• Chemical Biology Probes: Acts as a key building block for creating activity-based probes to study enzyme function and protein interactions.
• Pharmaceutical Intermediate: Employed in the synthesis of targeted drug candidates, including antibody-drug conjugates (ADCs).
• Materials Science Research: Facilitates the development of smart hydrogels, self-healing materials, and other functional networks via click chemistry.

Basic Information

Product Name	4-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)Benzene-1-Sulphonyl Azide
CAS No.	76464-67-0
Molecular Formula	C10H6N4O4S
Molecular Weight	278.24 g/mol
Synonyms	4-Maleimidobenzenesulfonyl Azide; p-Maleimidobenzenesulfonyl Azide; 1-(4-Azidosulfonylphenyl)-1H-pyrrole-2,5-dione; Maleimidophenyl Sulfonyl Azide; AMBS Azide; 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzenesulfonyl Azide; 4-(Maleimidoyl)benzenesulfonyl Azide; 4-(2,5-Dioxopyrrol-1-yl)benzenesulfonyl Azide
EINECS	Contact for details

Quality Control

Our production of 4-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)Benzene-1-Sulphonyl Azide adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize decomposition and oxidation. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.