Description

3-Bromo-2-Ketoglutarate is a specialized brominated derivative of α-ketoglutaric acid, serving as a crucial synthetic intermediate and biochemical probe. Its value lies in its unique reactivity, enabling the introduction of a bromine moiety into complex molecules for pharmaceutical and research applications. This compound is primarily needed by pharmaceutical R&D teams, biochemical researchers, and fine chemical manufacturers developing novel therapeutic agents and metabolic pathway modulators.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly enzyme inhibitors and targeted therapeutics.
• Biochemical Research: Used as a substrate analog or inhibitor in studies of metabolic enzymes, such as those in the Krebs cycle, to investigate enzyme mechanisms and regulation.
• Proteomics & Chemical Biology: Acts as a reactive handle for bioconjugation or as a precursor for activity-based probes to label and study specific enzyme families.
• Organic Synthesis: Serves as a versatile electrophile in C-C and C-X bond-forming reactions for constructing complex organic molecules with high functional group tolerance.
• Agrochemical Development: Potential intermediate in the research and synthesis of new, high-performance crop protection agents.

Basic Information

Product Name	3-Bromo-2-Ketoglutarate
CAS No.	76444-16-1
Molecular Formula	C5H5BrO5
Molecular Weight	225.00 g/mol
Synonyms	3-Bromo-2-oxoglutaric acid; 3-Bromo-2-oxopentanedioic acid; 3-Bromo-α-ketoglutaric acid; 2-Oxo-3-bromopentanedioic acid; Bromoketoglutaric acid; 3-Br-2-OG; 3-Bromo-2-ketoglutaric acid; 3-Bromo-2-oxo-1,5-pentanedioic acid
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Ketoglutarate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are kept sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.