Description

3-Chloro-4-Nitropyridine n-Oxide is a versatile and highly functionalized heterocyclic building block, primarily valued for its role as a key intermediate in advanced organic synthesis. Its unique structure, featuring both chloro and nitro substituents on the pyridine N-oxide ring, makes it a critical precursor for constructing complex molecules in pharmaceutical and agrochemical research. This compound is essential for chemists and manufacturers developing active pharmaceutical ingredients (APIs), specialty chemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other bioactive nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its reactive sites for structural diversification.
• Organic Synthesis Reagent: Serves as a versatile electrophile in nucleophilic aromatic substitution (SNAr) reactions and as a precursor for further functionalization (e.g., reduction, cross-coupling).
• Material Science Research: Employed in the development of specialty polymers, ligands for catalysis, and organic electronic materials due to its electron-deficient aromatic system.
• Chemical Research & Development: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	3-Chloro-4-Nitropyridine n-Oxide
CAS No.	76439-45-7
Molecular Formula	C5H3ClN2O3
Molecular Weight	174.54 g/mol
Synonyms	3-Chloro-4-nitropyridine 1-oxide; 3-Chloro-4-nitropyridine N-oxide; 4-Nitro-3-chloropyridine N-oxide; 3-Chloro-4-nitropyridine oxide; Pyridine, 3-chloro-4-nitro-, 1-oxide; 1-Oxido-3-chloro-4-nitropyridin-1-ium
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Nitropyridine n-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a dark location to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.