Description

(3Z,6E,10R)-9,10-Dihydro-10-Methyl-2H-Oxecin-2,5(8H)-Dione is a specialized, high-purity chemical intermediate characterized by its unique ten-membered oxecin ring structure. This compound matters for its role as a critical building block in the synthesis of complex natural products and novel pharmaceutical agents, where its stereochemistry and functional groups enable precise molecular construction. It is primarily needed by research institutions and pharmaceutical development companies engaged in advanced organic synthesis, medicinal chemistry, and the development of new therapeutic candidates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates, particularly those with macrocyclic or complex polyketide-like structures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for discovering new bioactive molecules.
• Natural Product Synthesis: Acts as a crucial precursor in the laboratory-scale total synthesis of complex natural products containing medium-sized lactone rings.
• Advanced Organic Synthesis: Employed in methodological development for ring-closing metathesis, lactonization, and other stereoselective transformations.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and research purposes in academic and industrial laboratories.

Basic Information

Product Name	(3Z,6E,10R)-9,10-Dihydro-10-Methyl-2H-Oxecin-2,5(8H)-Dione
CAS No.	76353-68-9
Molecular Formula	C10H14O3
Molecular Weight	182.22 g/mol
Synonyms	(3Z,6E,10R)-9,10-Dihydro-10-methyl-2H-oxecin-2,5(8H)-dione; 10-Methyl-9,10-dihydro-2H-oxecin-2,5(8H)-dione, (3Z,6E,10R)-; (3Z,6E,10R)-10-Methyl-9,10-dihydro-2H-oxecine-2,5(8H)-dione; (R,E,Z)-10-Methyl-9,10-dihydro-2H-oxecine-2,5(8H)-dione; 10-Methyl-9,10-dihydrooxecine-2,5-dione; A chiral oxecin dione intermediate
EINECS	Contact for details

Quality Control

Our (3Z,6E,10R)-9,10-Dihydro-10-Methyl-2H-Oxecin-2,5(8H)-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), and specific rotation is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be sensitive to prolonged exposure to heat and moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Specific Rotation	Provided on COA
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.