Description

3-Azabicyclo[3.1.0]Hexane-2-Carboxylicacid,Ethylester,[1R-(1-α-,2-α-,5-α-)]-(9Ci) is a high-purity, stereochemically defined bicyclic proline derivative. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and other bioactive molecules. The precise stereochemistry and high purity are essential for ensuring the efficacy and safety of the final drug products.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Peptidomimetic Chemistry: Used to introduce constrained, bicyclic proline analogs into peptides to enhance metabolic stability and receptor selectivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Chemical Biology Probe Development: Incorporated into molecular probes to study enzyme mechanisms and protein-protein interactions due to its rigid, three-dimensional structure.
• Agrochemical Research: Employed in the discovery and synthesis of new, stereospecific agrochemicals with improved activity profiles.

Basic Information

Product Name	3-Azabicyclo[3.1.0]Hexane-2-Carboxylicacid,Ethylester,[1R-(1-α-,2-α-,5-α-)]-(9Ci)
CAS No.	76319-28-3
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	(1R,2R,5S)-Ethyl 3-azabicyclo[3.1.0]hexane-2-carboxylate; (1R,2R,5S)-Ethyl 2-azabicyclo[3.1.0]hexane-3-carboxylate; Ethyl (1R,2R,5S)-3-azabicyclo[3.1.0]hexane-2-carboxylate; Bicycloproline ethyl ester; (1R,2R,5S)-Bicyclo[3.1.0]hexane-2-carboxylic acid ethyl ester, 3-aza-; Ethyl (1R,2R,5S)-2-azabicyclo[3.1.0]hexane-3-carboxylate; (1R,2R,5S)-3-Azabicyclo[3.1.0]hexane-2-carboxylic acid ethyl ester; 76319-28-3
EINECS	Contact for details

Quality Control

Our 3-Azabicyclo[3.1.0]Hexane-2-Carboxylicacid,Ethylester,[1R-(1-α-,2-α-,5-α-)]-(9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We ensure full traceability and compliance with global regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen) for prolonged operations to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.