Description

2-((tert-Butyldiphenylsilyl)Oxy)Acetic Acid is a versatile silyl-protected glycolic acid derivative, serving as a critical synthetic intermediate and protecting group reagent in advanced organic synthesis. Its primary value lies in enabling the selective protection of hydroxyl groups, facilitating complex multi-step reactions in the production of high-value target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors who require reliable, high-purity building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing glycolic acid or ethanolamine motifs.
• Peptide & Carbohydrate Chemistry: Used as a protecting group reagent for hydroxyl functionalities during the synthesis of complex peptides, glycopeptides, and oligosaccharides.
• Agrochemical Synthesis: Intermediate in the production of herbicides, fungicides, and plant growth regulators that require protected hydroxyl groups.
• Material Science Precursor: Serves as a monomer or modifying agent in the development of specialty polymers and functionalized surfaces.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and coupling reactions to introduce the (tert-butyldiphenylsilyl)oxy)acetyl moiety.
• Asymmetric Synthesis: Useful chiral auxiliary or starting material for the preparation of enantiomerically pure compounds.

Basic Information

Product Name	2-((tert-Butyldiphenylsilyl)Oxy)Acetic Acid
CAS No.	76271-74-4
Molecular Formula	C18H22O3Si
Molecular Weight	314.45 g/mol
Synonyms	2-[(tert-Butyldiphenylsilyl)oxy]acetic Acid; (TBDPS-O-Glycolic Acid); Acetic Acid, 2-[(1,1-dimethylethyl)diphenylsilyl]oxy]-; Glycolic Acid O-tert-Butyldiphenylsilyl Ether; O-(tert-Butyldiphenylsilyl)glycolic Acid; TBDPS-Glycolic Acid; 2-(tert-Butyldiphenylsiloxy)acetic Acid
EINECS	Contact for details

Quality Control

Our 2-((tert-Butyldiphenylsilyl)Oxy)Acetic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.