Description

(S)-1-Benzyl 5-Methyl 3-((tert-Butoxycarbonyl)Amino)Pentanedioate is a high-purity, chiral intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a key building block in the production of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide-mimetic drugs and protease inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce protected glutamic acid derivatives with specific stereochemistry.
• Research & Development: Serves as a valuable standard and starting material in medicinal chemistry for structure-activity relationship (SAR) studies and novel compound library generation.
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Bioconjugation: Can be utilized to create linkers or modified amino acid residues for antibody-drug conjugates (ADCs) and other bioconjugation strategies.

Basic Information

Product Name	(S)-1-Benzyl 5-Methyl 3-((tert-Butoxycarbonyl)Amino)Pentanedioate
CAS No.	76144-15-5
Molecular Formula	C19H27NO6
Molecular Weight	365.42 g/mol
Synonyms	(S)-1-Benzyl 5-methyl 3-((tert-butoxycarbonyl)amino)pentanedioate; (S)-3-((tert-Butoxycarbonyl)amino)-5-methyl-1-benzyl pentanedioate; Boc-D-Glu(OBzl)-OMe; Boc-D-Glutamic Acid α-Benzyl Ester Methyl Ester; (S)-1-Benzyl 5-methyl 3-((Boc)amino)pentanedioate; N-Boc-D-glutamic acid α-benzyl ester methyl ester; (S)-3-((Boc)amino)-5-methyl-1-benzyl pentanedioate; N-tert-Butoxycarbonyl-D-glutamic acid 1-benzyl ester 5-methyl ester
EINECS	Contact for details

Quality Control

Our (S)-1-Benzyl 5-Methyl 3-((tert-Butoxycarbonyl)Amino)Pentanedioate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity compliant with research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.