Description

(S)-(+)-1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid Monomethyl Ester is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a key building block for the production of enantiomerically pure calcium channel blockers and other active pharmaceutical ingredients (APIs). This compound is essential for research institutions and manufacturers in the pharmaceutical industry who require reliable, high-quality intermediates for process development and commercial-scale production.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiopure dihydropyridine-class calcium channel antagonists, such as S-Amlodipine.
• API Synthesis: Used in the research, development, and manufacturing of cardiovascular drugs and other therapeutic agents.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in chiral pool synthesis and asymmetric catalytic processes.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and the commercial production of complex drug molecules.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Chemical Research: Applied in academic and industrial R&D for exploring new medicinal chemistry pathways and novel bioactive compounds.

Basic Information

Product Name	(S)-(+)-1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid Monomethyl Ester
CAS No.	76093-34-0
Molecular Formula	C17H18N2O6
Molecular Weight	346.34 g/mol
Synonyms	(S)-Amlodipine Intermediate; (S)-Amlodipine Impurity; (S)-(+)-Amlodipine Related Compound A; (S)-3-Ethyl 5-Methyl 2-[(2-Aminoethoxy)methyl]-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate Precursor; (S)-Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; (S)-Methyl 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (S)-BAY o 5572 Intermediate; (S)-Enantiomer of Felodipine/Nifedipine Analog
EINECS	Contact for details

Quality Control

Our (S)-(+)-1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid Monomethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent pharmaceutical-grade standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.