Description

2-Mercapto-5-(Trifluoromethyl)Pyridine is a versatile heterocyclic building block characterized by a reactive thiol group and a trifluoromethyl substituent. This compound is highly valued for its role as a key intermediate in the synthesis of advanced pharmaceuticals and agrochemicals. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of modern pesticides, herbicides, and fungicides, where the trifluoromethyl group improves lipophilicity and biological efficacy.
• Ligand & Catalyst Preparation: Serves as a building block for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and electronic materials requiring specific fluorine-containing motifs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	2-Mercapto-5-(Trifluoromethyl)Pyridine
CAS No.	76041-72-0
Molecular Formula	C6H4F3NS
Molecular Weight	179.16 g/mol
Synonyms	5-(Trifluoromethyl)pyridine-2-thiol; 2-Pyridinethiol, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2-mercaptopyridine; 2-Mercapto-5-trifluoromethylpyridine; 2-Thiol-5-trifluoromethylpyridine; 5-Trifluoromethyl-2-pyridinethiol; 2-SH-5-CF3-Pyridine
EINECS	Contact for details

Quality Control

Our 2-Mercapto-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP and ISO standards for traceability and reliability in your supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.