Description

α-D-Ribofuranose, 5-o-[(1,1-Dimethylethyl)dimethylsilyl]-2,3-o-(1-methylethylidene)- is a protected ribose derivative, a crucial building block in organic synthesis. This compound is essential for the controlled introduction of ribose moieties, enabling the synthesis of complex nucleosides, nucleotides, and other bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer drugs, and other therapeutic oligonucleotides.

Application

• Nucleoside & Nucleotide Synthesis: A key protected intermediate for the preparation of modified nucleosides used in antiviral and anticancer research.
• Oligonucleotide Chemistry: Serves as a building block in solid-phase synthesis for creating RNA analogs and antisense oligonucleotides.
• Carbohydrate Chemistry Research: Used in studies involving glycosylation reactions and the synthesis of complex sugar derivatives.
• Pharmaceutical Intermediate: Critical for the R&D and production of active pharmaceutical ingredients (APIs) targeting viral diseases.
• Bioconjugation: Facilitates the site-specific attachment of sugars to proteins, peptides, or other biomolecules.
• Chemical Biology Probes: Enables the creation of labeled ribose derivatives for metabolic pathway studies and diagnostic applications.

Basic Information

Product Name	α-D-Ribofuranose, 5-o-[(1,1-Dimethylethyl)dimethylsilyl]-2,3-o-(1-methylethylidene)-
CAS No.	75921-21-0
Molecular Formula	C16H32O5Si
Molecular Weight	332.51 g/mol
Synonyms	5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-D-ribofuranose; 2,3-O-Isopropylidene-5-O-(tert-butyldimethylsilyl)-D-ribofuranose; 5-O-TBDMS-2,3-O-isopropylidene-D-ribofuranose; 5-O-(tert-Butyldimethylsilyl)-2,3-O-(1-methylethylidene)-D-ribofuranose; D-Ribofuranose, 5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-; TBDMS-protected isopropylidene ribose; Protected D-ribose derivative
EINECS	Contact for details

Quality Control

Our α-D-Ribofuranose, 5-o-[(1,1-Dimethylethyl)dimethylsilyl]-2,3-o-(1-methylethylidene)- is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP standards where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.