Description

4-Trimethylsilylethynylbenzonitrile is a high-purity, functionalized aromatic nitrile compound featuring a trimethylsilyl-protected ethynyl group. This unique structure makes it a valuable advanced intermediate and building block in sophisticated organic synthesis, particularly for constructing complex molecular architectures. It is primarily utilized by pharmaceutical R&D and advanced material science laboratories for applications such as drug discovery and the development of organic electronic materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring conjugated alkyne systems.
• Organic Electronic Materials: Used in the research and development of organic semiconductors, light-emitting diodes (OLEDs), and other optoelectronic devices due to its electron-withdrawing nitrile group and π-conjugated system.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands used in catalysis and coordination chemistry.
• Cross-Coupling Reactions: An effective substrate in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form complex biaryl and extended conjugated systems.
• Polymer Chemistry: A monomer or modifier for synthesizing specialty polymers with tailored thermal, optical, or electronic properties.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and constructing molecular probes.

Basic Information

Item	Detail
Product Name	4-Trimethylsilylethynylbenzonitrile
CAS No.	75867-40-2
Molecular Formula	C₁₂H₁₃NSi
Molecular Weight	199.33 g/mol
Synonyms	4-((Trimethylsilyl)ethynyl)benzonitrile; p-(Trimethylsilylethynyl)benzonitrile; Benzonitrile, 4-[(trimethylsilyl)ethynyl]-; 4-(Trimethylsilylethynyl)benzonitrile; TMS-Ethynylbenzonitrile; 4-Cyanophenyl(trimethylsilyl)acetylene
EINECS	Contact for details

Quality Control

Our 4-Trimethylsilylethynylbenzonitrile is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the specified 97% minimum purity. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.