Description

5''-Bromospiro[1,3-Dioxolane-2,3''-Indol]-2''(1''H)-One is a specialized brominated spirocyclic oxindole derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. This compound matters for its unique molecular architecture, which provides a versatile scaffold for constructing complex heterocyclic systems and pharmacologically active molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of novel bioactive compounds targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those with spirocyclic or oxindole cores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization.
• Organic Synthesis Reagent: Serves as a versatile electrophile or scaffold for constructing complex heterocycles and fused ring systems.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the production of active pharmaceutical ingredients (APIs).
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with novel modes of action.
• Academic Research: Used in methodological studies exploring new spirocyclization reactions and bromination chemistry.

Basic Information

Product Name	5''-Bromospiro[1,3-Dioxolane-2,3''-Indol]-2''(1''H)-One
CAS No.	75822-54-7
Molecular Formula	C11H8BrNO3
Molecular Weight	282.09 g/mol
Synonyms	5'-Bromospiro[1,3-dioxolane-2,3'-indolin]-2'-one; 5-Bromospiro[1,3-dioxolane-2,3-indol]-2(1H)-one; 5'-Bromo-1',3'-dihydrospiro[1,3-dioxolane-2,3'-indol]-2'-one; 5-Bromospiro[indoline-3,2'-[1,3]dioxolan]-2-one; 75822-54-7; Bromospirooxindole dioxolane
EINECS	Contact for details

Quality Control

Our 5''-Bromospiro[1,3-Dioxolane-2,3''-Indol]-2''(1''H)-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and elemental analysis. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.