Description

3-Butynoic Acid, 2-[(Methoxycarbonyl)Amino]-4-(Trimethylsilyl)-, Methyl Ester is a specialized, high-purity synthetic intermediate featuring both a protected alkyne and a silyl-protected functional group. This compound is critical for advanced organic synthesis, particularly in the construction of complex molecular architectures where precise functional group manipulation is required. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as peptide mimetics, heterocycle synthesis, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring alkyne or silyl ether functionalities for further coupling reactions (e.g., Sonogashira, Click chemistry).
• Agrochemical Research: Used in the development of novel active ingredients, where its unique structure can contribute to new modes of action or improved stability profiles.
• Peptidomimetics & Conjugation: Serves as a valuable synthon for creating non-natural amino acid analogs and for bioconjugation strategies in drug delivery and diagnostic agent development.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the research of specialty polymers and advanced organic materials with tailored properties.
• Academic & R&D Laboratories: Employed in methodological studies and the discovery of new synthetic pathways in organic chemistry.

Basic Information

Product Name	3-Butynoic Acid, 2-[(Methoxycarbonyl)Amino]-4-(Trimethylsilyl)-, Methyl Ester
CAS No.	75806-14-3
Molecular Formula	C11H19NO4Si
Molecular Weight	257.36 g/mol
Synonyms	Methyl 2-[(Methoxycarbonyl)Amino]-4-(Trimethylsilyl)-3-butynoate; 2-[(Methoxycarbonyl)Amino]-4-(Trimethylsilyl)-3-butynoic Acid Methyl Ester; Methyl N-Methoxycarbonyl-4-(trimethylsilyl)dehydroalaninate; 4-(Trimethylsilyl)-2-[(methoxycarbonyl)amino]-3-butynoic Acid Methyl Ester; TMS-Protected Dehydroalanine Derivative; N-Carbomethoxy-4-(trimethylsilyl)dehydroalanine Methyl Ester
EINECS	Contact for details

Quality Control

Our production of 3-Butynoic Acid, 2-[(Methoxycarbonyl)Amino]-4-(Trimethylsilyl)-, Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.