Description

5-o-(tert-Butyldiphenylsilyl)-1,2-o-Isopropylidene-α-D-Erythro-Pentofuranos-3-Ulose CAS NO 75783-45-8 is a high-purity, protected carbohydrate derivative, specifically a silylated and isopropylidene-protected pentofuranos-3-ulose. This compound serves as a critical chiral building block and advanced synthetic intermediate for the production of complex nucleosides, antiviral agents, and other bioactive molecules. It is essential for researchers and manufacturers in pharmaceutical development, fine chemical synthesis, and advanced organic chemistry who require high-quality, structurally defined intermediates for complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside analogs and antiviral drugs.
• Fine Chemical Synthesis: Serves as a chiral scaffold for constructing complex natural products and specialty chemicals.
• Glycochemistry Research: Used in the study and development of modified sugars and carbohydrate-based therapeutics.
• Process Chemistry: Employed in route development and scale-up for Active Pharmaceutical Ingredient (API) manufacturing.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis and asymmetric catalysis.
• Bioconjugate Chemistry: Potential use in creating labeled or modified biomolecules for diagnostic applications.

Basic Information

Product Name	5-o-(tert-Butyldiphenylsilyl)-1,2-o-Isopropylidene-α-D-Erythro-Pentofuranos-3-Ulose
CAS No.	75783-45-8
Molecular Formula	C24H30O5Si
Molecular Weight	426.58 g/mol
Synonyms	1,2-O-Isopropylidene-5-O-(tert-butyldiphenylsilyl)-α-D-erythro-pentofuranos-3-ulose; 5-O-TBDPS-1,2-O-isopropylidene-α-D-ribofuranos-3-ulose; 3-Keto-5-O-(tert-butyldiphenylsilyl)-1,2-O-isopropylidene-α-D-ribofuranose; TBDPS-protected isopropylidene ribofuranos-3-ulose; 75783-45-8; α-D-Erythro-pentofuranos-3-ulose, 5-O-(1,1-dimethylethyl)dimethylsilyl-1,2-O-(1-methylethylidene)-
EINECS	Contact for details

Quality Control

Our 5-o-(tert-Butyldiphenylsilyl)-1,2-o-Isopropylidene-α-D-Erythro-Pentofuranos-3-Ulose is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure identity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.