Description

5-o-(tert-Butyldimethylsilyl)-2,3-o-Isopropylidene-D-Ribonic Acid γ-Lactone is a high-purity, protected sugar lactone derivative that serves as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its primary value lies in providing a versatile, stereochemically defined scaffold for constructing complex nucleoside analogs and other bioactive molecules. This compound is essential for research and development laboratories in the pharmaceutical, agrochemical, and fine chemical industries, where precise control over molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer drug discovery.
• Chiral Building Block: Used in asymmetric synthesis to introduce the D-ribose moiety into complex natural products and active pharmaceutical ingredients (APIs).
• Carbohydrate Chemistry Research: Fundamental reagent for studying glycosylation reactions and developing new protecting group strategies in sugar chemistry.
• Agrochemical Synthesis: Intermediate in the production of certain chiral herbicides and plant growth regulators.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	5-o-(tert-Butyldimethylsilyl)-2,3-o-Isopropylidene-D-Ribonic Acid γ-Lactone
CAS No.	75467-36-6
Molecular Formula	C14H26O5Si
Molecular Weight	302.44 g/mol
Synonyms	2,3-O-Isopropylidene-5-O-(tert-butyldimethylsilyl)-D-ribono-1,4-lactone; 5-O-TBDMS-2,3-O-isopropylidene-D-ribono-1,4-lactone; D-Ribono-1,4-lactone, 5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-; 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-D-ribonolactone; Protected D-Ribonolactone; TBDMS-Protected Isopropylidene Ribonolactone
EINECS	Contact for details

Quality Control

Our 5-o-(tert-Butyldimethylsilyl)-2,3-o-Isopropylidene-D-Ribonic Acid γ-Lactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.