Description

1H-Pyrrole-1-Carboxylic Acid, 2-(Trimethylsilyl)-, 1,1-Dimethylethyl Ester is a high-value, protected pyrrole derivative that serves as a critical synthetic intermediate. This compound is essential for facilitating complex organic transformations, particularly in the construction of nitrogen-containing heterocycles, where its protecting groups offer superior stability and selectivity. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those containing pyrrole or indole cores.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides that require specific nitrogen heterocycle frameworks.
• Material Science Research: Serves as a precursor for the development of advanced organic electronic materials and conductive polymers.
• Organic Synthesis: A versatile reagent for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) and other metal-mediated transformations.
• Protecting Group Strategy: The tert-butyl ester and trimethylsilyl groups provide orthogonal protection for pyrrole nitrogen and C-2 position, enabling multi-step synthetic sequences.
• Academic & Contract Research: Essential for methodological development and exploring new reaction pathways in university and CRO laboratory settings.

Basic Information

Product Name	1H-Pyrrole-1-Carboxylic Acid, 2-(Trimethylsilyl)-, 1,1-Dimethylethyl Ester
CAS No.	75400-57-6
Molecular Formula	C12H23NO2Si
Molecular Weight	241.40 g/mol
Synonyms	2-(Trimethylsilyl)-1H-pyrrole-1-carboxylic acid tert-butyl ester; tert-Butyl 2-(trimethylsilyl)-1H-pyrrole-1-carboxylate; 1-(tert-Butoxycarbonyl)-2-(trimethylsilyl)pyrrole; 1-Boc-2-(trimethylsilyl)pyrrole; 2-TMS-1H-pyrrole-1-Boc; N-Boc-2-(trimethylsilyl)pyrrole; 2-Trimethylsilyl-1H-pyrrole-1-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrole-1-Carboxylic Acid, 2-(Trimethylsilyl)-, 1,1-Dimethylethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.