Description

5-Bromo-2-{[2-Methyl-3-(Trifluoromethyl)Phenyl]Amino}Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its distinct halogenated and trifluoromethyl-substituted aromatic structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting specific receptor pathways. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for developing next-generation therapeutic agents, where its unique molecular framework enables precise modulation of drug activity and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates, especially in medicinal chemistry programs.
• API Development: Used in research and development for creating new Active Pharmaceutical Ingredients, leveraging its bromo and trifluoromethyl functional groups for structure-activity relationship (SAR) studies.
• Biochemical Research: Employed as a standard or reagent in biochemical assays and pharmacological research to investigate enzyme inhibition or receptor binding.
• Agrochemical Synthesis: Potential application as an intermediate in the development of advanced agrochemicals, such as herbicides or pesticides, due to its halogenated aniline structure.
• Material Science Research: Can be investigated as a monomer or building block for specialty polymers or organic electronic materials.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	5-Bromo-2-{[2-Methyl-3-(Trifluoromethyl)Phenyl]Amino}Nicotinic Acid
CAS No.	75369-60-7
Molecular Formula	C14H10BrF3N2O2
Molecular Weight	375.14 g/mol
Synonyms	5-Bromo-2-[(2-methyl-3-(trifluoromethyl)phenyl)amino]nicotinic acid; 5-Bromo-2-{[2-methyl-3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid; 2-Amino-5-bromo-N-[2-methyl-3-(trifluoromethyl)phenyl]nicotinic acid; Nicotinic acid, 5-bromo-2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-; 75369-60-7; 5-Bromo-2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinic acid
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-{[2-Methyl-3-(Trifluoromethyl)Phenyl]Amino}Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP guidelines for pharmaceutical applications, and we support regulatory documentation for global markets including REACH and FDA submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere if necessary and opened only in a moisture-controlled environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.