Description

Lovastatin CAS NO 75330-75-5 is a potent, naturally occurring statin derived from *Aspergillus terreus* and other fungi. It serves as a critical pharmaceutical active ingredient, functioning as a competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthesis pathway. This compound is essential for manufacturers in the pharmaceutical industry developing cholesterol-lowering medications and for researchers investigating lipid metabolism and cardiovascular disease.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key component in prescription medications for managing hypercholesterolemia and reducing the risk of cardiovascular events.
• Generic Drug Formulation: Serves as the core API for the production of generic lovastatin tablets and other oral dosage forms.
• Biochemical Research: Used as a standard and tool compound in laboratory studies focusing on cholesterol synthesis, enzyme kinetics, and metabolic pathways.
• Nutraceutical & Dietary Supplements: Employed in the formulation of specific dietary supplements aimed at supporting healthy cholesterol levels, subject to regional regulatory approvals.
• Veterinary Pharmaceuticals: Potential application in veterinary medicine for lipid management in companion and livestock animals.
• Intermediate for Derivatives: Acts as a starting material or intermediate for the semi-synthesis of other statin drugs or novel chemical entities.

Basic Information

Product Name	Lovastatin
CAS No.	75330-75-5
Molecular Formula	C24H36O5
Molecular Weight	404.55 g/mol
Synonyms	Mevinolin; Monacolin K; 6α-Methylcompactin; [1S-[1α(R*),3α,7β,8β(2S*,4S*),8aβ]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2-methylbutanoate; MK-803; Lovalord; MSD 803
EINECS	278-137-7

Quality Control

Our Lovastatin is manufactured and tested under strict quality management systems. We offer grades suitable for pharmaceutical applications, with specifications that can meet relevant pharmacopoeial standards (e.g., USP, EP). Every batch undergoes comprehensive analytical testing including HPLC assay, related substances analysis, identification, and residual solvent testing to ensure identity, purity, and potency. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Water (Karl Fischer)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.