Description

(10Z,13S,14S)-14-Pentyl-13-[(Trimethylsilyl)Oxy]Oxacyclotetradeca-10-En-2-One CAS NO 75299-44-4 is a high-purity, stereochemically defined macrolide intermediate featuring a strategically positioned trimethylsilyl (TMS) protecting group. This compound is of significant value for its role in the synthesis of complex natural products and bioactive molecules, where precise stereochemistry and functional group manipulation are critical. It is primarily sought after by research institutions and pharmaceutical development teams engaged in advanced organic synthesis and medicinal chemistry projects.

Application

• Advanced Organic Synthesis Intermediate: Serves as a key chiral building block for the construction of complex macrolide and polyketide frameworks.
• Pharmaceutical Research & Development: Used in the synthesis of novel drug candidates, particularly in antibiotic and anticancer research where macrolide structures are prevalent.
• Natural Product Synthesis: A critical precursor in the total synthesis of naturally occurring bioactive compounds for structure-activity relationship (SAR) studies.
• Methodology Development: Employed in academic and industrial labs to develop new asymmetric synthesis and protecting group strategies.
• Process Chemistry: Utilized in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs) during process optimization phases.

Basic Information

Product Name	(10Z,13S,14S)-14-Pentyl-13-[(Trimethylsilyl)Oxy]Oxacyclotetradeca-10-En-2-One
CAS No.	75299-44-4
Molecular Formula	C22H42O3Si
Molecular Weight	382.66 g/mol
Synonyms	14-Pentyl-13-[(trimethylsilyl)oxy]oxacyclotetradeca-10-en-2-one, (10Z,13S,14S)-; (10Z,13S,14S)-14-Pentyl-13-(trimethylsiloxy)oxacyclotetradec-10-en-2-one; TMS-protected macrolide intermediate; (10Z,13S,14S)-14-Pentyl-13-(TMS-oxy)oxacyclotetradeca-10-en-2-one; Chiral macrolactone TMS ether; 13-(Trimethylsilyloxy)-14-pentyloxacyclotetradec-10-en-2-one
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, stereochemical purity, and chemical purity. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Enantiomeric Excess (Chiral HPLC)	≥ 98% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.