Description

Lovastatin Sodium Salt is the water-soluble sodium salt form of lovastatin, a potent and selective inhibitor of HMG-CoA reductase. This form offers enhanced bioavailability and solubility, making it a critical intermediate in the production of advanced pharmaceutical formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions for the development and production of cholesterol-lowering medications and related biochemical studies.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key starting material or intermediate in the synthesis of finished dosage forms of statin-based cholesterol medications.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to investigate pharmacokinetics, efficacy, and new delivery systems for hyperlipidemia treatments.
• Reference Standard: Serves as a high-purity analytical standard for quality control and assay development in pharmaceutical laboratories.
• Biochemical Research: Employed in enzymatic studies to specifically inhibit HMG-CoA reductase and explore cholesterol biosynthesis pathways.
• Formulation Development: Utilized in creating injectable or highly soluble oral formulations where the sodium salt's improved dissolution profile is advantageous.

Basic Information

Product Name	Lovastatin Sodium Salt
CAS No.	75225-50-2
Molecular Formula	C24H35NaO5
Molecular Weight	426.53 g/mol
Synonyms	Lovastatin Sodium; Monacolin K Sodium Salt; Mevinolin Sodium Salt; (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl (2S)-2-methylbutanoate Sodium Salt; 6α-Methylcompactin Sodium Salt; MK-803 Sodium Salt
EINECS	Contact for details

Quality Control

Our Lovastatin Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) are provided with every shipment, detailing all test results against relevant pharmacopeial standards (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
pH (5% solution)	7.0 - 9.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.