Description

Methyl-4-Azidobenzoylaminoacetimidate is a specialized organic compound featuring an azido functional group, making it a valuable building block for click chemistry and bioconjugation applications. Its primary value lies in enabling efficient, high-yield coupling reactions under mild, aqueous conditions, which is critical for modifying biomolecules and polymers. This reagent is essential for researchers and manufacturers in pharmaceutical development, materials science, and chemical biology who require precise and reliable cross-linking agents.

Application

• Bioconjugation Reagent: Used for site-specific labeling of proteins, antibodies, and oligonucleotides via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC).
• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, particularly for creating antibody-drug conjugates (ADCs) and targeted therapeutics.
• Polymer Functionalization: Enables the modification of polymer backbones to introduce bioactive ligands or alter material properties for advanced biomaterials and hydrogels.
• Proteomics Research: Facilitates the study of protein-protein interactions and cellular pathways through activity-based protein profiling (ABPP) and labeling strategies.
• Diagnostic Agent Synthesis: Employed in the development of contrast agents and probes for molecular imaging techniques.
• Surface Immobilization: Used to create functionalized surfaces on chips, beads, or plates for biosensor development and microarray technology.

Basic Information

Product Name	Methyl-4-Azidobenzoylaminoacetimidate
CAS No.	75221-89-5
Molecular Formula	C11H11N5O2
Molecular Weight	245.24 g/mol
Synonyms	Methyl (4-azidobenzoyl)aminoacetimidate; 4-Azidobenzoylaminoacetimidic Acid Methyl Ester; Acetimidic acid, N-[(4-azidophenyl)carbonyl]-, methyl ester; Methyl N-(4-azidobenzoyl)acetimidate; Azido-PEG1-NHS Ester (related compound); Click Chemistry Reagent 75221-89-5; Azide Functionalized Benzoyl Reagent
EINECS	Contact for details

Quality Control

Our Methyl-4-Azidobenzoylaminoacetimidate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to the light-sensitive nature of the azido group, prolonged exposure to light should be avoided. Keep the container sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.