Description

n-Formyl γ-Carboxyglutamic Acid γ,γ-Di-T-Butyl 3-Ethyl Ester is a high-purity, protected amino acid derivative used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise control over peptide and protein structure, particularly for introducing post-translational modifications. It is primarily utilized in pharmaceutical R&D for the development of novel therapeutics, including anticoagulants and treatments for metabolic bone disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of peptides and proteins containing γ-carboxyglutamic acid (Gla) residues, which are vital for the biological activity of various blood coagulation factors and bone proteins.
• Biochemical Research: Used in studying vitamin K-dependent carboxylation processes and the structure-activity relationships of Gla-containing proteins.
• Proteomics & Peptide Chemistry: Enables the site-specific incorporation of modified amino acids into synthetic peptides for drug discovery and diagnostic agent development.
• Anticoagulant Drug Development: Serves as a building block for synthesizing analogs of natural anticoagulants like Protein C and Factor IX.
• Bone Metabolism Studies: Applied in research focused on osteocalcin and other bone Gla proteins involved in calcium homeostasis and bone formation.

Basic Information

Product Name	n-Formyl γ-Carboxyglutamic Acid γ,γ-Di-T-Butyl 3-Ethyl Ester
CAS No.	75117-30-5
Molecular Formula	C₁₇H₂₇NO₇
Molecular Weight	357.40 g/mol
Synonyms	N-Formyl-γ-carboxy-L-glutamic acid γ,γ-di-tert-butyl 3-ethyl ester; Fmoc-Gla(OtBu)₂-OH (common protected form analog); γ-Carboxyglutamic Acid Derivative; N-Formyl-L-γ-carboxyglutamic Acid 1,5-Di-tert-butyl 3-Ethyl Ester; Gla(OtBu)₂ Protected Amino Acid; 3-Ethyl N-formyl-γ,γ-di-tert-butoxycarbonylglutamate; (2S)-2-Formamido-4,4-bis(tert-butoxy)-4-oxobutanoic Acid Ethyl Ester; Protected Gla Residue
EINECS	Contact for details

Quality Control

Our n-Formyl γ-Carboxyglutamic Acid γ,γ-Di-T-Butyl 3-Ethyl Ester is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.