Description

3,17β-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-7α-Ol is a high-purity, protected steroid derivative, specifically a trimethylsilyl (TMS) ether of estradiol. This compound is a crucial advanced pharmaceutical intermediate and a protected synthon for the synthesis of complex steroid-based molecules. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel hormonal therapies and other bioactive steroidal compounds.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel estradiol derivatives and other steroidal active pharmaceutical ingredients (APIs).
• Research & Development: Used in academic and industrial research for studying steroid metabolism, receptor binding, and structure-activity relationships (SAR).
• Hormone Analog Synthesis: Serves as a protected precursor for creating modified estrogen analogs with potential therapeutic applications.
• Fine Chemical Production: Employed in the custom synthesis of high-value, complex steroidal compounds for specialized markets.
• Reference Standard: Can be utilized as a chromatographic or spectroscopic reference standard in analytical method development and quality control.

Basic Information

Item	Detail
Product Name	3,17β-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-7α-Ol
CAS No.	75113-12-1
Molecular Formula	C24H40O3Si2
Molecular Weight	432.75 g/mol
Synonyms	7α-Hydroxyestradiol 3,17-bis(trimethylsilyl) ether; Estra-1,3,5(10)-triene-3,17β-diol, 7α-hydroxy-, 3,17-bis(trimethylsilyl) ether; 7α-Hydroxyestradiol bis-TMS ether; 3,17β-Bis(trimethylsiloxy)estra-1,3,5(10)-trien-7α-ol; 75113-12-1; 7α-Hydroxy-17β-estradiol 3,17-bis-O-(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our 3,17β-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-7α-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.