Description

3-[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Triene-16,17-Dione Bis(o-Methyl Oxime) is a high-purity, advanced steroid derivative featuring a trimethylsilyl (TMS) protecting group and bis-oxime functionality. This compound is a critical intermediate in the synthesis of complex steroidal molecules, offering precise control over chemical transformations. It is primarily utilized by pharmaceutical research and development organizations, as well as fine chemical manufacturers, for the production of active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of steroidal drugs and hormones.
• Research Chemical: Used in academic and industrial R&D for exploring new synthetic pathways and creating novel steroid analogs.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Fine Chemical Synthesis: Employed in the production of specialized, high-value steroidal compounds for various applications.
• Process Development: Used to optimize and scale up synthetic routes for steroidal APIs under GMP conditions.

Basic Information

Item	Details
Product Name	3-[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Triene-16,17-Dione Bis(o-Methyl Oxime)
CAS No.	75113-02-9
Molecular Formula	C23H36N2O3Si
Molecular Weight	416.64 g/mol
Synonyms	16,17-Dioxoestra-1,3,5(10)-trien-3-yl Trimethylsilyl Ether Bis(O-Methyloxime); 3-Trimethylsilyloxyestra-1,3,5(10)-triene-16,17-dione dioxime methyl ether; Estra-1,3,5(10)-triene-16,17-dione, 3-[(trimethylsilyl)oxy]-, bis(O-methyloxime); 3-TMS-O-Estra-1,3,5(10)-triene-16,17-dione bis(O-methyloxime); 16,17-Bis(methoxyimino)estra-1,3,5(10)-trien-3-ol Trimethylsilyl Ether
EINECS	Contact for details

Quality Control

Our 3-[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Triene-16,17-Dione Bis(o-Methyl Oxime) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.