Description

((3Ar,5R,6S,6Ar)-2,2-Dimethyl-6-(((trifluoromethyl)sulfonyl)oxy)tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl 4-methylbenzoate is a high-purity, advanced pharmaceutical intermediate characterized by its complex, functionalized carbohydrate-like structure. This compound is of significant value in organic synthesis, particularly for its role as a key chiral building block in the development of nucleoside analogs and other bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of antiviral agents, anticancer drugs, and other complex therapeutic compounds where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer research.
• Antiviral Drug Development: Used in constructing the sugar backbone of potential therapeutic agents targeting viruses such as hepatitis, influenza, and herpes.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and the creation of targeted molecular libraries.
• Process Chemistry: Employed in route scouting and scale-up processes for the production of active pharmaceutical ingredients (APIs) requiring specific stereocenters.
• Glycochemistry & Glycobiology: Acts as a protected and activated glycosyl donor or acceptor analog in the synthesis of complex carbohydrates and glycomimetics.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations specializing in custom synthesis for clinical trial material production.

Basic Information

Product Name	((3Ar,5R,6S,6Ar)-2,2-Dimethyl-6-(((trifluoromethyl)sulfonyl)oxy)tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl 4-methylbenzoate
CAS No.	75096-61-6
Molecular Formula	C19H21F3O8S
Molecular Weight	466.43 g/mol
Synonyms	5-O-(p-Toluoyl)-2,3-O-isopropylidene-1-O-triflyl-β-D-ribofuranose; 1-O-((Trifluoromethyl)sulfonyl)-2,3-O-isopropylidene-5-O-(4-methylbenzoyl)-β-D-ribofuranose; 5-O-(4-Methylbenzoyl)-1-O-trifluoromethanesulfonyl-2,3-O-isopropylidene-β-D-ribofuranose; 1-O-Triflyl-2,3-O-isopropylidene-5-O-p-toluoyl-β-D-ribofuranose; β-D-Ribofuranose, 5-O-(4-methylbenzoyl)-1-O-[(trifluoromethyl)sulfonyl]-, 2,3-O-(1-methylethylidene)-; Trifluoromethanesulfonic acid 2,3-O-isopropylidene-5-O-p-toluoyl-β-D-ribofuranosyl ester
EINECS	Contact for details

Quality Control

Our ((3Ar,5R,6S,6Ar)-2,2-Dimethyl-6-(((trifluoromethyl)sulfonyl)oxy)tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl 4-methylbenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.