Description

(1R)-Dibromo-1,2,3,4,5,6-Hexahydro-1,5-Methano-8H-Pyrido[1,2-A][1,5]Diazocin-8-One is a high-purity, advanced pharmaceutical intermediate with a complex, bridged polycyclic structure. This compound is valued for its role as a key chiral building block in the synthesis of sophisticated active pharmaceutical ingredients (APIs), particularly in neurological and therapeutic research. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of complex drug molecules targeting the central nervous system.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing novel chemical libraries in drug discovery programs.
• Asymmetric Synthesis: Serves as a substrate or intermediate in catalytic asymmetric reactions to introduce stereochemical complexity.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for potential API candidates.
• Academic Research: Utilized in universities and research institutes for studies in organic methodology and heterocyclic chemistry.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for custom synthesis projects.

Basic Information

Product Name	(1R)-Dibromo-1,2,3,4,5,6-Hexahydro-1,5-Methano-8H-Pyrido[1,2-A][1,5]Diazocin-8-One
CAS No.	74987-72-7
Molecular Formula	C12H12Br2N2O
Molecular Weight	372.05 g/mol
Synonyms	(1R)-8,9-Dibromo-2,3,4,4a,5,6-hexahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one; (1R)-Dibromohexahydromethanopyridodiazocinone; 74987-72-7; (1R)-enantiomer of the dibromo derivative; Pyrido[1,2-a][1,5]diazocin-8-one, (1R)-dibromohexahydro-1,5-methano-; Bridged diazocinone intermediate
EINECS	Contact for details

Quality Control

Our (1R)-Dibromo-1,2,3,4,5,6-Hexahydro-1,5-Methano-8H-Pyrido[1,2-A][1,5]Diazocin-8-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccant in the storage container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.